Analytical Sciences


Cover image of volume 35, number 1

Volume 35, Number 1 (2019)

Cover illustration of this month"Recent Progress in Chemical Modification of Proteins" by Seiji SAKAMOTO and Itaru HAMACHI (p.5). See larger image


Highlights − Volume 35, Number 1 (2019)

Speciation of Chromium
Nobuhiko IKI
Analytical Sciences, 2019, 35(1), 1.
DOI: 10.2116/analsci.highlights1901
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Hot Articles − Volume 35, Number 1 (2019)

hot article mark
Electrochemical Biosensing System for Single Cells, Cellular Aggregates and Microenvironments
Hitoshi SHIKU
Keywords: Scanning electrochemical microscopy, scanning ion conductance microscopy, single cell analysis, gene expression, cell chip, reporter system, embryoid body, mass spectrometry
Analytical Sciences, 2019, 35(1), 29.
DOI: 10.2116/analsci.18SDR01


Table of Contents − Volume 35, Number 1 (2019)

Highlights

Speciation of Chromium
Nobuhiko IKI
Analytical Sciences, 2019, 35(1), 1.
DOI: 10.2116/analsci.highlights1901
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Special Issue:New Insights and Concepts of Biological Sciences Based on Cell and Biomolecule Analysis

Guest Editorial

“New Insights and Concepts of Biological Sciences Based on Cell and Biomolecule Analysis”
Keitaro Yoshimoto and Noritada Kaji
Analytical Sciences, 2019, 35(1), 3.
DOI: 10.2116/analsci.GE1901

Reviews

Recent Progress in Chemical Modification of Proteins
Seiji SAKAMOTO and Itaru HAMACHI
Keywords: Protein chemical modification, site-selective protein modification, recognition driven protein labeling, ligand-directed chemistry, affinity-guided catalyst chemistry
Analytical Sciences, 2019, 35(1), 5.
DOI: 10.2116/analsci.18R003
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hot article mark
Electrochemical Biosensing System for Single Cells, Cellular Aggregates and Microenvironments
Hitoshi SHIKU
Keywords: Scanning electrochemical microscopy, scanning ion conductance microscopy, single cell analysis, gene expression, cell chip, reporter system, embryoid body, mass spectrometry
Analytical Sciences, 2019, 35(1), 29.
DOI: 10.2116/analsci.18SDR01
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Original Papers

Electrochemical Imaging of Cell Activity in Hydrogels Embedded in Grid-shaped Polycaprolactone Scaffolds Using a Large-scale Integration-based Amperometric Device
Kosuke INO, Yuki YOKOKAWA, Noriko TAIRA, Atsushi SUDA, Ryota KUNIKATA, Yuji NASHIMOTO, Tomokazu MATSUE, and Hitoshi SHIKU
Keywords: Electrochemical bioimaging, LSI-based amperometric device, multiple detection, printed polycaprolactone, cell culture in hydrogels, embryonic stem cell
Analytical Sciences, 2019, 35(1), 39.
DOI: 10.2116/analsci.18SDP01
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Mechanical Properties of the Coat Protein Layer and Cortex in Single Bacillus subtilis Spores Studied with an Atomic Force Microscope and Laser-induced Surface Deformation Microscope
Toshinori MORISAKU, Yuriko KIDO, Kei ASAI, and Hiroharu YUI
Keywords: Spore, dynamic viscoelastic property, power-law, LISD microscope, AFM
Analytical Sciences, 2019, 35(1), 45.
DOI: 10.2116/analsci.18SDP02
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Influence of Culture Conditions on Cell Proliferation in a Microfluidic Channel
Kae SATO, Miwa SATO, Mizuho YOKOYAMA, Mai HIRAI, and Aya FURUTA
Keywords: Microfluidics, cell, cell culture medium, metabolism, perfusion culture
Analytical Sciences, 2019, 35(1), 49.
DOI: 10.2116/analsci.18SDP04
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Membrane Dynamics Induced by a Phosphatidylinositol 3,4,5-Trisphosphate Optogenetic Tool
Yoshibumi UEDA, Tatsuhito II, Yuki AONO, Naotoshi SUGIMOTO, Seiichi SHINJI, Hiroshi YOSHIDA, and Moritoshi SATO
Keywords: Lipid, phosphatidylinositol 3,4,5-trisphosphate, PIP3, optogenetics, cryptochrome 2, lamellipodia, structured illumination microscopy
Analytical Sciences, 2019, 35(1), 57.
DOI: 10.2116/analsci.18SDP06
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An Application of Photoactivatable Substrate for the Evaluation of Epithelial-mesenchymal Transition Inhibitors
Jun NAKANISHI, Kenji SUGIYAMA, Hirotaka MATSUO, Yoko TAKAHASHI, Satoshi OMURA, and Takuji NAKASHIMA
Keywords: Collective cell migration, epithelial-mesenchymal transition, leader cells, cancer, drug screening, nanaomycin, patterning, caged compound, mechanobiology, transforming growth factor β
Analytical Sciences, 2019, 35(1), 65.
DOI: 10.2116/analsci.18SDP07
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In vitro Determination of Rapamycin-triggered FKBP–FRB Interactions Using a Molecular Tension Probe
Sung Bae KIM, Ryo NISHIHARA, Rika FUJII, Ramasamy PAULMURUGAN, Daniel CITTERIO, and Koji SUZUKI
Keywords: Molecular tension probe, protein–protein interactions, artificial luciferase, bioluminescence, in vitro assay, imaging
Analytical Sciences, 2019, 35(1), 71.
DOI: 10.2116/analsci.18SDP08
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Tyrosinase-mediated Peptide Conjugation with Chitosan-coated Gold Nanoparticles
Naomi SAKONO, Kosuke NAKAMURA, Tatsuki OHSHIMA, Ryoto HAYAKAWA, and Masafumi SAKONO
Keywords: Bioconjugation, caspase-3 activity assay, functional nanoparticles, tyrosinase
Analytical Sciences, 2019, 35(1), 79.
DOI: 10.2116/analsci.18SDP03
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Synthesis of a Peptide-Human Telomere DNA Conjugate as a Fluorometric Imaging Reagent for Biological Sodium Ion
Shinobu SATO, Yuuki IMAICHI, Yukiko YOSHIURA, Koji NAKAZAWA, and Shigeori TAKENAKA
Keywords: Peptide-oligonucleotide conjugate, FAM, TAMRA, sodium ion, potassium ion, antiparallel tetraplex, hybrid tetraplex, fluorometric imaging
Analytical Sciences, 2019, 35(1), 85.
DOI: 10.2116/analsci.18SDP05
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A Benzothiazole-based Ratiometric Fluorescent Probe for Benzoyl Peroxide and Its Applications for Living Cells Imaging
Xiaohua MA, Guoguang WU, Yuehua ZHAO, Zibo YUAN, Ning XIA, Mengnan YANG, and Lin LIU
Keywords: Fluorescent probe, benzothiazole, benzoyl peroxide, cell imaging
Analytical Sciences, 2019, 35(1), 91.
DOI: 10.2116/analsci.18SDP09
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Notes

Array-based Generation of Response Patterns with Common Fluorescent Dyes for Identification of Proteins and Cells
Masahiro MIMURA, Shunsuke TOMITA, Ryoji KURITA, and Kentaro SHIRAKI
Keywords: Biosensing, cancer cells, fluorescent dyes, multivariate analysis, proteins
Analytical Sciences, 2019, 35(1), 99.
DOI: 10.2116/analsci.18SDN01
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Fabrication of a Flexible Biosensor Based on an Organic Field-effect Transistor for Lactate Detection
Tsukuru MINAMIKI, Shizuo TOKITO, and Tsuyoshi MINAMI
Keywords: Organic transistors, flexible biosensors, lactate, enzymes, redox polymers
Analytical Sciences, 2019, 35(1), 103.
DOI: 10.2116/analsci.18SDN02
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A Novel Proof-of-Concept Sandwich Immunoassay for Screening Microcystin in Cyanobacteria Based on Michael Addition Reaction
Chenlin HU and Jiyoung LEE
Keywords: Microcystin, free form, sandwich immunoassay, Michael addition reaction, ELISA
Analytical Sciences, 2019, 35(1), 107.
DOI: 10.2116/analsci.18SDN03
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Screening of DNA Signaling Aptamer from Multiple Candidates Obtained from SELEX with Next-generation Sequencing
Toru YOSHITOMI, Fumiya WAYAMA, Keiko KIMURA, Koji WAKUI, Hitoshi FURUSHO, and Keitaro YOSHIMOTO
Keywords: Signaling aptamer, VEGF receptor, VEGFR-1, VEGFR-2, SELEX, next generation sequencing analysis, high-throughput sequencing, G-quadruplex
Analytical Sciences, 2019, 35(1), 113.
DOI: 10.2116/analsci.18SDN05
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Announcements

Analytical Sciences, 2019, 35(1), 117.
DOI: 10.2116/analsci.announce1901