Abstract − Analytical Sciences, 37(3), 539 (2021).
Investigations of Chirality Effects on Undifferentiated State of Mesenchymal Stem Cells Using Soft Nanofibrous Oligopeptide Hydrogels
Toru YOSHITOMI,*,** Hangyu ZHENG,*,*** and Keitaro YOSHIMOTO*
*Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro, Tokyo 153-8902, Japan
**Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 Japan
***Present Address: Institute for Frontier Life and Medical Sciences, Kyoto University, Yoshidahonmachi, Sakyo, Kyoto 606-8507, Japan
**Research Center for Functional Materials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 Japan
***Present Address: Institute for Frontier Life and Medical Sciences, Kyoto University, Yoshidahonmachi, Sakyo, Kyoto 606-8507, Japan
Soft nanofibrous oligopeptide hydrogels consisting of self-assembled l- and d-form Fmoc-Phe-Phe-Cys networks photo-cross-linked by poly(ethylene glycol)-dimethacrylate, which are referred to as l- and d-gel, respectively, were developed for investigation of chirality effects on the undifferentiated state of mesenchymal stem cells. Encapsulated mesenchymal stem cells in d-gel showed slower growth and less spreading, resulting in higher maintenance of the undifferentiated state, compared to in l-gel. This indicates that d-form peptide materials might be useful as scaffold materials for regenerative medicine using stem cells.
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