Analytical Sciences

Paper-based Chemiluminescence Device with Co-Fe Nanocubes for Sensitive Detection of Caffeic Acid

Liu ZHANG, Yue HOU, Xiaoyan GUO, Wei LIU, Congcong LV, Xing PENG, and Zixuan ZHANG

Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, P. R. China

In this work, a new chemiluminescence (CL) system of Co-Fe prussian blue analogs nanocubes (Co-Fe PBA NCs) that can catalyze luminol to produce strong CL in the absence of H₂O₂ was established. Co-Fe PBA NCs have the property of oxidase-like activity, and it can catalyze the generation of active oxygen radicals in a dissolved oxygen system. Since caffeic acid (CA) can remove reactive oxygen species in the system, a sensitive detection method for CA on a paper-based chip was developed. Under the optimal conditions, this method showed a good linear response to CA in the range of 10 – 800 ng mL⁻¹ with a limit of 3 ng mL⁻¹. The proposed method had been used for the determination of CA in tea samples. The results may open a new avenue for the catalytic property on luminol CL system without extra oxidants.

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