Analytical Sciences

Non-invasive and Time-dependent Blood-sugar Monitoring via Breath-derived CO₂ Correlation Using Gas Chromatograph with a Milli-whistle Gas Analyzer

Cheng-Huang LIN,*1 Luo-Xian WU,*1 Kuan-Hao CHEN,*1 Hsu-Feng LO,*1 King-Chuen LIN,*2 Toshio KASAI,*2,*3 Chien-Chung CHEN,*4 Chung-Hung SHIH,*5,*6 Maria Carla MANZANO,*7 Gil Nonato SANTOS,*7 Enrique MANZANO,*7,*8 and Derrick Ethelbhert YU*9

*1 Department of Chemistry, National Taiwan Normal University, Tingchow Rd., Taipei 10617, Taiwan
*2 Department of Chemistry, National Taiwan University, Roosevelt Rd., Taipei 10617, Taiwan
*3 Institute of Scientific and industrial Research, Osaka University, Ibaraki, Osaka 567-0047, Japan
*4 Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Wu-Hsing St., Taipei 11031, Taiwan
*5 School of Respiratory Therapy, Taipei Medical University, Wu-Hsing St., Taipei 11031, Taiwan
*6 Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan
*7 Physics Department, De La Salle University, 2401 Taft Ave., Manila 0922, Philippines
*8 Electronics and Communications Engineering Department, De La Salle University, 2401 Taft Ave., Manila 0922, Philippines
*9 Chemistry Department, De La Salle University, 2401 Taft Ave., Manila 0922, Philippines

A clear and positive correlation between the CO₂ concentration and the blood-sugar level has been observed via a non-invasive and time-dependent monitoring of CO₂ concentration from human breath, which is carried out by using a home-made gas chromatography (GC)/milli-whistle compact analyzer. The time-dependent sampling of the CO₂ concentration correlated between 5.0 to 5.6% (1% = 10⁴ ppm) in accordance with blood-sugar level variations of 80 to 110 mg/dL. The analytical method results in a rapid, continuous and non-invasive determination of blood-sugar level via measurement of the CO₂ concentration exhaled from the lungs.

J-STAGE: View this article in J-STAGE