Analytical Sciences

A Facile Colorimetric Sensor for 6-Mercaptopurine Based on Silver Nanoparticles

Junling DUAN, Yijing LI, Qin HOU, Wei LV, Li DAI, and Shiyun AI

College of Chemistry and Material Science, Shandong Agricultural University, Tai’an, Shandong 271018, P. R. China

A facile colorimetric method was developed for detecting 6-mercaptopurine (6-MP) using silver nanoparticles (AgNPs). The addition of 6-MP to AgNPs led to the aggregation of AgNPs with a color change from yellow to brown. The ratio between the absorbance at 394 and 530 nm (A₃₉₄/A₅₃₀) was used for a quantitative analysis of 6-MP. A linear range of 0 – 0.5 μM was obtained with a detection limit of 10 nM. The developed method is cost-effective and simple.

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