Analytical Sciences

An Exploration of Advancement in Analytical Methodology for Quantification of Anticancer Drugs in Biomatrices

Sonali JAIN, Tarang JADAV, Amit Kumar SAHU, Kiran KALIA, and Pinaki SENGUPTA

National Institute of Pharmaceutical Education and Research (NIPER)—Ahmedabad, Gujarat, India

Significant numbers of newer anticancer drugs are regularly entering into the market worldwide to fight against different types of cancers. Analytical methodologies are being developed to quantitate those molecules in a variety of matrices during their drug development stages. Selection of biological matrices for developing bioanalytical methods is based on the mechanism of action, site of action, site of metabolism and route of excretion of the drugs or their metabolites. In this review, we have described the current scenario and advancements in bioanalytical techniques for quantification of different anticancer drugs in a variety of biomatrices with a special emphasis on sample preparation techniques. We have discussed and summarized different bioanalytical aspects for anticancer drugs, which can give direction to the researcher for choosing appropriate techniques for their quantification needs.

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