Analytical Sciences

Towards Green Titration: Downscaling the Sequential Injection Analysis Lab-at-valve Titration System with the Stepwise Addition of a Titrant

Pathinan PAENGNAKORN,*1,*2 Saiphon CHANPAKA,*3,*4 Kanchana WATLA-IAD,*3,*5 Wasin WONGWILAI,*1,*6 and Kate GRUDPAN*1,*3

*1 Center of Excellence for Innovation in Analytical Science and Technology, Chiang Mai University, Chiang Mai 50200, Thailand
*2 Biomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand
*3 Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
*4 Presently at Department of General Science, Faculty of Science and Engineering, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakhon Nakhon 47000, Thailand
*5 Presently at School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
*6 Science and Technology Research Institute, Chiang Mai University, Chiang Mai 50200, Thailand

A downscaling in true titration based on a simple sequential injection analysis-lab-at-valve (SIA-LAV) has been proposed. A titrant solution was stepwise aspirated into a titration LAV chamber and a titration curve was obtained by monitoring the change in the solution color spectroscopically. This fully-automated SIA-LAV system required less volume of the sample/reagents, only a micro-liter scale, compared to the conventional method. The system was investigated with complexometric titration and acid-base titration. Application of the developed technique to some real samples has been demonstrated.

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