Analytical Sciences

Applications and Uncertainty Estimation of Single Level Standard Addition Method ICP-MS for Elemental Analysis in Various Matrix

Yanbei ZHU,*1 Kazumi NAKANO,*2 Zhongyuan WANG,*3 Yasuyuki SHIKAMORI,*2 Koichi CHIBA,*4 Takayoshi KUROIWA,*1 Akiharu HIOKI,*1 and Kazumi INAGAKI*1

*1 National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono, Tsukuba, Ibaraki 305-8563, Japan
*2 Agilent Technologies Japan, Ltd., 9-1 Takakura, Hachioji, Tokyo 192-8510, Japan
*3 South China Sea Environment Monitoring Center, State Oceanic Administration, 155 Xingang West Road, Guangzhou 510300, China
*4 Graduate School of Science and Technology, Kwansei Gakuin University, 1-1-155 Uegahara, Nishinomiya, Hyogo 662-8501, Japan

The standard addition method (SAM) based on gravimetric sample preparation was investigated as an approach for the removal or cancelling of matrix effects in measurements by inductively coupled plasma mass spectrometry (ICP-MS). Deduction of the equations and experimental confirmation of the method are both given in the present work. After measuring both spiked and non-spiked samples by ICP-MS, the concentration of an element could be calculated based on the signal intensity ratio to an internal standard. A practical example was provided for the measurement of Fe in a certified reference material (CRM), i.e. NMIJ CRM 7512-a (milk powder). The validity of the method had been confirmed by the results of international comparisons with various kinds of matrix, including bioethanol, human serum, biodiesel fuel, drinking water, infant formula milk power, and seafood. The suggested method had been applied to measurements of multiple elements in three CRMs, including tap water, milk powder, and tea leave powder, respectively.

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