Analytical Sciences

Preparation of Complexes between Ovalbumin Nanoparticles and Retinoic Acid for Efficient Induction of Tolerogenic Dendritic Cells

Khadijah ZAI,*1 Kazuki YUZURIHA,*2 Akihiro KISHIMURA,*1,*2,*3,*4 Takeshi MORI,*1,*2,*3 and Yoshiki KATAYAMA*1,*2,*3,*4,*5,*6

*1 Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan
*2 Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan
*3 Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan
*4 International Research Center for Molecular Systems, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan
*5 Centre for Advanced Medicine Innovation, Kyushu University, 3-1-1 Maidashi, Higashi, Fukuoka 812-8582, Japan
*6 Department of Biomedical Engineering, Chung Yuan Christian University, 200 Chung Pei Rd., Chung Li, 32023 ROC, Taiwan

The induction of antigen-specific immunotolerance has been gathering attention concerning the therapy of allergy and autoimmune diseases. Tolerogenic dendritic cells (tDCs) play crucial roles in immunotolerance therapy because they induce anergic responses for auto-reactive helper T cells, and also enhance differentiation to regulatory T cells to maintain tolerance against auto-antigens. All-trans retinoic acid (ATRA) is one of the representative molecules used to induce tDCs. We have proposed a simple formulation of ovalbumin nanoparticles complexed with ATRA (OVA/RA NPs). OVA/RA NPs were taken up by DCs and successfully induced phenotypes of tDCs.

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