Analytical Sciences

Quantitative Measurement of Protein Using Metal Mesh Device

Seiji KAMBA,*,** Hirokazu SETO,** Takashi KONDO,* and Yoshiko MIURA**

*Murata Manufacturing Co., Ltd., 1-10-1 Higashikotari, Nagaokakyo, Kyoto 617-8555, Japan
**Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi, Fukuoka 819-0395, Japan

Biosensing of protein adsorption with metal mesh device (MMD) was investigated by computational calculations and experiments. Electromagnetic field computation was carried out with a single unit cell of MMD. Equivalent circuit model of MMD on the single unit cell was assumed, and the biosensing with MMD was analyzed in detail by computational calculation and experimental measurements. The dip frequency of MMD was shifted by adsorption of protein on MMD. The shift of dip frequency of MMD was proportional to the amount of protein adsorption. The sensitivity of MMD biosensing was dependent on the microstructure of MMD, and proportional to the square of the dip frequency. The refinement of MMD structure can improve the sensitivity of protein detection.

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