Abstract − Analytical Sciences, 33(7), 789 (2017).
Rapid Detection of Diazepam Injection Based on Surface Enhanced Raman Spectroscopy
Si-qin-gao-wa HAN,*1 Lin BAO,*2 Mei-Ling ZHANG,*3 Xiang LIN,*4 and Wu-Li-Ji HASI*3
*1 Affiliated Hospital, Inner Mongolia University for the Nationalities, Inner Mongolia Tongliao 028007, P. R. China
*2 College of Physics and Electronics Information Inner Mongolia University for Nationalities, Inner Mongolia Tongliao 028043, P. R. China
*3 National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, P. R. China
*4 School of Physics and Materials Engineering, Dalian Nationalities University, Dalian 116600, P. R. China
*2 College of Physics and Electronics Information Inner Mongolia University for Nationalities, Inner Mongolia Tongliao 028043, P. R. China
*3 National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, P. R. China
*4 School of Physics and Materials Engineering, Dalian Nationalities University, Dalian 116600, P. R. China
Diazepam injection was detected based on a droplet surface enhanced Raman spectroscopy (SERS) platform, which overcomes the disadvantages of the poor uniformity and time-consuming sample treatment process of the conventional “drop and dry” detection strategy. The Raman peak positions of diazepam injection were determined and identified, they are mainly located in the 689, 1002, 1170 and 1598 cm−1, etc. Different concentrations of diazepam injection were detected. It was found that the intensity of 1002 cm−1 increases linearly with concentration in the range from 0.05 to 10 μg/mL and the linear correlation coefficient is 0.988. The limit of detection can reach 0.05 μg/mL. The SERS method is easy, fast and efficient. The results are accurate and reliable. It has favorable application potential in the detection of diazepam injection.
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