Abstract − Analytical Sciences, 33(6), 743 (2017).
Simultaneous Quantitation of Boric Acid and Calcium Fructoborate in Dietary Supplements by HPTLC–Densitometry
Andrei BITA,*1 George Dan MOGOSANU,*1 Ludovic Everard BEJENARU,*1 Carmen Nicoleta OANCEA,*2 Cornelia BEJENARU,*3 Octavian CROITORU,*4 Gabriela RAU,*5 Johny NEAMTU,*2 Iulia Daria SCOREI,*6 Ion Romulus SCOREI,*6 John HUNTER,*7 Brad EVERS,*7 Boris NEMZER,*7 Florin ANGHELINA,*8 and Otilia-Constantina ROGOVEANU*9
*1 Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*2 Department of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*3 Department of Vegetal & Animal Biology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*4 Department of Drug Control, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*5 Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*6 BioBoron Research Institute, University of Craiova, Mircesti Street, Bldg. M4/1/1, 200506 Craiova, Romania
*7 VDF FutureCeuticals, 2692 N. State Rt. 1-17, Momence, IL 60954, USA
*8 Department of Otorhinolaryngology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*9 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*2 Department of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*3 Department of Vegetal & Animal Biology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*4 Department of Drug Control, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*5 Department of Organic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*6 BioBoron Research Institute, University of Craiova, Mircesti Street, Bldg. M4/1/1, 200506 Craiova, Romania
*7 VDF FutureCeuticals, 2692 N. State Rt. 1-17, Momence, IL 60954, USA
*8 Department of Otorhinolaryngology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
*9 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania
The paper describes a new, simple, selective and precise high-performance thin-layer chromatographic (HPTLC) method for the simultaneous identification and quantitative determination of boric acid (BA) and calcium fructoborate (CFB) in bulk and tablet/capsule dosage forms of dietary supplements. HPTLC silica gel G 60 F254 precoated glass plates were used as the stationary phase. The mobile phase consisted of 2-propanol–water 8:2 (v/v). The two boron-based compounds were adequately separated with the Rf values of 0.83 ± 0.01 (BA) and 0.59 ± 0.01 (CFB).
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