Analytical Sciences

Transduction Function of a Magnetic Nanoparticle TMADM for Stem-Cell Imaging with Quantum Dots

Yusuke OGIHARA,*1,*2 Hiroshi YUKAWA,*1,*2 Daisuke ONOSHIMA,*2,*3 and Yoshinobu BABA*1,*2,*3,*4,*5

*1 Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan
*2 ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan
*3 Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan
*4 Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu 761-0395, Japan
*5 College of Pharmacy, Kaohsiung Medical University, 100, Shin-Chuan 1st Rd., Kaohsiung, 807, Taiwan, R. O. C.

We investigated the transduction function of a cationic dextran hydroxypropyltrimethyl ammonium chloride-coated magnetic iron oxide nanoparticle (TMADM-03) for transducing quantum dots (QDs) into adipose tissue-derived stem cells (ASCs). As a result, the fluorescence intensity of ASCs labeled with QDs using TMADM-03 was much higher than that of QDs only labeling. These data suggest that TMADM-03 can be useful as a transduction agent for QDs in stem-cell imaging.

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