Abstract − Analytical Sciences, 33(12), 1421 (2017).
A Planar Bilayer Lipid Membrane Sensor Using a Miniaturized Auto-patch System
Taiga ZAMOTO,* Satoshi TOMINAGA,* Masato NISHIO,** Atsushi SHOJI,*** and Masao SUGAWARA*
*Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajosui, Setagaya, Tokyo 156-8550, Japan
**Bio Research Center Co., Ltd., Towa Takaoka Building, 2-28-2 Izumi, Higashi, Nagoya 461-0001, Japan
***Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
**Bio Research Center Co., Ltd., Towa Takaoka Building, 2-28-2 Izumi, Higashi, Nagoya 461-0001, Japan
***Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
A bilayer lipid membrane sensor was constructed with a miniaturized auto-patch system. The performance of the patch system was optimized to obtain an analytically relevant signal. A biosensor based on an anti-BSA-antibody as a receptor and gramicidin as a signal transduction element was demonstrated. The sensor for BSA exhibited a detection limit of pg/mL level for BSA.
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