Analytical Sciences

Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs

Rojeet SHRESTHA,*1 Ken-ichi HIRANO,*2,*3 Akira SUZUKI,*2 Satoshi YAMAGUCHI,*2 Yusuke MIURA,*1 Yi-Fan CHEN,*4 Masahiro MIZUTA,*4 Hitoshi CHIBA,*1 and Shu-Ping HUI*1

*1 Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan
*2 Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Osaka 565-0874, Japan
*3 Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0874, Japan
*4 Laboratory of Advance Data Science, Information Initiative Center, Hokkaido University, Sapporo 060-0811, Japan

We studied change in the plasma total, esterified and non-esterified capric acid (FA10:0) and its effect on longer fatty acid concentrations during the short-term oral administration of synthetic tricaprin in dogs. We administered 150 and 1500 mg tricaprin/kg body weight per day orally to dogs for 7 consecutive days. Blood samples were collected at 0, 0.5, 1, 2, 4, 8, and 24 h on the 1st and 7th days for measuring the total-, esterified- and non-esterified-FA10:0. The total-FA10:0 concentration increased in a dose-dependent manner, reaching a peak at 1 h on the 1st day and at 2 to 4 h on the 7th day; it then mostly disappeared within 24 h. The mean esterified FA10:0 concentration was found be 75.5 and 60.3% of total-FA10:0 in dogs fed 150 and 1500 mg of tricaprin/kg body weight, respectively. The plasma level of FA10:0 depends on the duration and dose of tricaprin administration, but are rapidly cleared from circulation within several hours.

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