Analytical Sciences

Use of CuO Particles as an Interface in LC-FTIR Analysis

Yan LI,*1,*2 Ran GUO,*2,*3 Shengnan LIU,*2,*4 Anqi HE,*2,*5 Yanan BAO,*2,*6 Shifu WENG,*2 Yaping HUANG,*1 Yizhuang XU,2,*5 Yukihiro OZAKI,*2,*7 Isao NODA,*2,*8 and Jinguang WU*2

*1 Nanyang Institute of Technology, Nanyang 473000, P. R. China
*2 Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
*3 College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, P. R. China
*4 College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, P. R. China
*5 Ninghai Doubly Advanced Materials Co., Ltd., Ninghai 315602, P. R. China
*6 Liaoning Technical University, Fuxin 123000, P. R. China
*7 Department of Chemistry, School of Science, Kwansei Gakuin University, Sanda, Hyogo 669-1337, Japan
*8 Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA

In this study, the feasibility of using copper oxide (CuO) as an interface for the coupling of liquid chromatography (LC) and Fourier-transform infrared (FTIR) spectroscopy was investigated. CuO exhibits low absorption in the 4000 to 1000 cm⁻¹ FTIR spectral region. In addition, LC-FTIR using CuO as the interface was extended to the analysis of sample mixtures containing benzamide and dioctyl sebacate; both analytes were successfully separated. After complete removal of the mobile phase, benzamide and dioctyl sebacate were successfully identified from the FTIR spectrum. Surprisingly, the interference from adsorbed water or conventionally used LC solvents in the FTIR spectrum was completely eliminated by using CuO particles as the interface in the off-line hyphenation of LC-FTIR. Based on these results, CuO demonstrates potential as an ideal interface for LC-FTIR analysis.

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