Analytical Sciences

Fluorometric Determination of Epinephrine: A Green Approach

Shalini MENON,* S. JESNY,** Unni SIVASANKARAN,* and Krishnapillai GIRISH KUMAR*

*Department of Applied Chemistry, Cochin University of Science and Technology, Kochi-682022, India
**Sree Narayana College, Cherthala, Kerala-688582, India

Herein, a simple, sensitive and selective turn-on fluorescent method for the determination of epinephrine (EP), an important hormone and neurotransmitter, is described. The method is based on the interaction of EP with PEG₆₀₀₀ coated carbon nanoparticles (PCN) resulting in the fluorescence enhancement of PCN. A linear relationship was obtained between the fluorescence intensity and concentration of EP in the 9.90 × 10⁻⁹ – 1.07 × 10⁻⁷ M range; the detection limit being 7.59 × 10⁻¹⁰ M. Furthermore, we demonstrated the application of the present approach in a synthetic urine sample, which suggested its great potential for diagnostic purposes.

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