Analytical Sciences

Micropillars Fabricated on Poly(methyl methacrylate) Substrates for Separation of Microscale Objects

Takao YASUI,*1,*2 Satoru ITO,*1 Noritada KAJI,*1,*2,*3 Manabu TOKESHI,*2,*4 and Yoshinobu BABA*1,*2,*5

*1 Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan
*2 ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan
*3 ERATO Higashiyama Live-Holonics Project, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8603, Japan
*4 Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita, Sapporo 060-8628, Japan
*5 Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan

Development of polymeric microfluidic devices has played an important role in the recent, rapid progress of biomedical research. Here we report a fabrication method for micropillars on poly(methyl methacrylate) (PMMA) substrates for separation of microscale objects. The fabricated micropillars enable continuous separation of microparticles only by introducing fluids. The present method offers a new strategy to fabricate polymeric prototype devices for R&D work.

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