Abstract − Analytical Sciences, 30(8), 817 (2014).
A Fluorescence Probe Based on Biomolecule-stabilized Gold Nanoclusters for the Detection of Pazufloxacin Mesilate
Xueling CAO,*,** Lili LIAN,*,** Hongwei LI,* Yuqing WU,* and Dawei LOU**
*State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699, Qianjin Street, Changchun 130012, P. R. China
**Department of Chemistry, Jilin Institute of Chemical Technology, No. 45 Chengde Street, Jilin 132022, P. R. China
**Department of Chemistry, Jilin Institute of Chemical Technology, No. 45 Chengde Street, Jilin 132022, P. R. China
In the present study, biomolecule-stabilized Au nanoclusters were demonstrated as a novel fluorescence probe for sensitive and selective detection of pazufloxacin mesilate (PZFX) for the first time. The linear decrease in the fluorescence intensity of Au nanoclusters induced by PZFX allowed for the quantitative detection of PZFX in the range of 0.15 μg/mL to 1 mg/mL, and the detection limit for PZFX was 0.2 μg/mL. Circular dichroism spectroscopy and fluorescence decay studies were then performed to discuss the quenching mechanism. In addition, practical application of the present approach was also demonstrated for real samples, which suggested its great potential for accurate analysis of similar drugs.
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