Analytical Sciences

Pore-forming Compounds as Signal Transduction Elements for Highly Sensitive Biosensing

Masao SUGAWARA,* Atsushi SHOJI,** and Misato SAKAMOTO*

*Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajyosui, Setagaya, Tokyo 156-8550, Japan
**School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Pore-forming compounds are attracting much attention due to the signal transduction ability for the development of highly sensitive biosensing. In this review, we describe an overview of the recent advances made by our group in the design of molecular sensing interfaces of spherical and planar lipid bilayers and natural bilayers. The potential uses of pore-forming compounds, such as gramicidin and MCM-41, in lipid bilayers and natural glutamate receptor channels in biomembrane are presented.

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