Analytical Sciences

Spectrophotometric Sequential Injection Determination of D-Penicillamine Based on a Complexation Reaction with Nickel Ion

Anita MARTINOVIC-BEVANDA* and Njegomir RADIC**

*Department of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88 000 Mostar, Bosnia and Herzegovina
**Department of Analytical Chemistry, Faculty of Chemistry and Technology, University of Split, Teslina 10/V, 21 000 Split, Croatia

A simple and sensitive spectrophotometric method, based on reaction between Ni(II) ion and D-penicillamine (PEN), was developed. The proposed SIA system enhanced the analytical applicability of the reaction of complexation, and allowed the determination of PEN in the concentration range of 3.0 × 10⁻⁶ – 2.0 × 10⁻⁴ mol L⁻¹ with a sampling rate of 200 h⁻¹. With the proposed SIA system, PEN could be accurately determinated up to 0.9 nmol quantity. The method was successfully applied to the determination of PEN in laboratory samples and pharmaceuticals.

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