Analytical Sciences

Electrochemistry of Metoclopramide at Multi-walled Carbon Nanotube Modified Electrode and Its Voltammetric Detection

Wei GUO,* Mingjiang GENG,* and Lingyun ZHOU**

*Department of Chemistry, Xinxiang Medical University, East of JinSui Road, Xinxiang, Henan 453003, P. R. China
**College of Resource and Environment, Henan Institute of Science and Technology, East of HuaLan Road, Xinxiang, Henan 453003, P. R. China

A simple, sensitive and inexpensive electrochemical method was developed for the determination of metoclopramide (MCP) with a multi-wall carbon nanotube (MWNT) modified glassy carbon electrode (GCE). MWNT was dispersed into polyacrylic acid (PAA); the aqueous suspension was then cast on GCE electrodes, forming MWNT-PAA ?lms after evaporation of the solvent. The electrochemical behavior of MCP at the MWNT-modified electrode was investigated in detail. Compared with the bare GCE, the MWNT-modified electrode exhibits electrocatalytic activity to the oxidation of MCP because of the significant oxidation peak-current enhancement. Furthermore, various experimental parameters, such as the solution pH value, the amount of MWNT-PAA suspension and accumulation conditions were optimized for the determination of MCP. Based on the electrocatalytic effect of the MWNT-modified electrode, linear sweep voltammetry (LSV) was developed for the determination of MCP with the linear response in the range from 1.0 × 10⁻⁷ to 1.0 × 10⁻⁵ mol L⁻¹ and a detection limit of 5.0 × 10⁻⁸ mol L⁻¹. The method has been successfully applied to the determination of MCP in commercial MCP tablets.

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