Analytical Sciences

Inhibition of Electrochemical Fouling against Biomolecules on a Diamond-Like Carbon Electrode

Takuya GOTO,* Tomoyuki YASUKAWA,*,** Kazuhiro KANDA,*** Shinji MATSUI,*** and Fumio MIZUTANI*

*Graduate School of Material Science, University of Hyogo, 3-2-1 Kouto, Kamigori, Ako-gun, Hyogo 678-1297, Japan
**JST-CREST, 5 Sanbancho, Chiyoda, Tokyo 102-0075, Japan
***Laboratory of Advanced Science and Technology for Industry, University of Hyogo, 3-1-2 Kouto, Kamigori, Ako-gun, Hyogo 678-1205, Japan

An anti-fouling ability of diamond-like carbon (DLC) electrodes to biological macromolecules has been investigated from a decrease in the electrochemical redox current of Fe(CN)₆^4−/3−, used as a redox marker. A DLC electrode and a glassy carbon (GC) electrode were immersed in a solution containing bovine serum albumin (BSA) or DNA. The GCs treated with biological macromolecules gave rise to a significant decrease in the currents, while there was no signal decreases from the treated DLCs. The signals from the DLCs remain essentially unchanged for at least 24 h at a 10 mg/mL concentration level of BSA.

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