Analytical Sciences

Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry

Tadashi OGAWA,*1 Hideki HATTORI,*1 Rina KANEKO,*2 Kenjiro ITO,*1 Masayo IWAI,*1 Yoko MIZUTANI,*1 Tetsuya ARINOBU,*3 Akira ISHII,*2 Osamu SUZUKI,*4 and Hiroshi SENO*1

*1 Department of Legal Medicine, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
*2 Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine, 65 Tsuruma, Showa, Nagoya 466-8550, Japan
*3 Department of Chemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
*4 Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi, Hamamatsu 431-3192, Japan

A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C₁₈ column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01 – 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.

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