Abstract − Analytical Sciences, 25(12), 1483 (2009).
Terahertz Absorption Spectra of Original and Generic Ceftazidime
Masaya KAWASE,*1,*2 Tadashi SAITO,*2 Masafumi OGAWA,*3 Hideki UEJIMA,*3 Yasutoshi HATSUDA,*3 Sonoyo KAWANISHI,*3 Yoshihiko HIROTANI,*3 Michiaki MYOTOKU,*3 Kenji IKEDA,*3 Keisuke TAKANO,*4 Masanori HANGYO,*4 Kohji YAMAMOTO,*5 and Masahiko TANI*5
*1 Nagahama Institute of Bio-science and Technology, 1266 Tamura, Nagahama, Shiga 526-0829, Japan
*2 Radioisotope Research Center, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan
*3 Faculty of Pharmaceutical Sciences, Osaka Ohtani University, 3-11-1 Nishikiorikita, Tondabayashi, Osaka 584-8540, Japan
*4 Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, Japan
*5 Research Center for Development of Far-Infrared Region, University of Fukui, 3-9-1 Bunkyo, Fukui 901-8507, Japan
*2 Radioisotope Research Center, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan
*3 Faculty of Pharmaceutical Sciences, Osaka Ohtani University, 3-11-1 Nishikiorikita, Tondabayashi, Osaka 584-8540, Japan
*4 Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871, Japan
*5 Research Center for Development of Far-Infrared Region, University of Fukui, 3-9-1 Bunkyo, Fukui 901-8507, Japan
The absorption spectra of ceftazidime and its generic versions (Modacin, Mosyl, and Mobenzocin) have been measured by terahertz time domain spectroscopy (THz-TDS). Differences in the THz absorption were observed between the original and generic versions. The results show small, but significant differences in the states of ceftazidime hydrate between the original and generic versions. THz-TDS can be used to evaluate the stability of medicines as well as to control their quality.
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