Analytical Sciences

Abstract − Analytical Sciences, 24(9), 1093 (2008).

Polarographic Behavior of Nicotinamide in Surfactant Media and Its Determination in Cetyltrimethylammonium Bromide Surfactant System
Rahul M. KOTKAR and Ashwini K. SRIVASTAVA
Department of Chemistry, University of Mumbai, Vidyanagari, Santacruz (East), Mumbai-400 098, India
The behavior of nicotinamide has been studied by differential pulse polarography and cyclic voltammetry in the presence of certain ionic and nonionic surfactants, viz. cetyltrimethylammonium bromide (CTAB), sodium dodecylsulfate (SDS) and Triton X-100 (TX-100). The cathodic peak potential (Epc) and peak current (Ipc) of nicotinamide were found to be remarkably dependent on the charge and concentration of the surfactant. The presence of SDS and that of TX-100 cause a shift in peak potential and a change in peak current of nicotinamide. In the presence of the cationic surfactant, CTAB, an enhancement in the sensitivity of nicotinamide was observed. A sharp peak with more than two-fold increase in current was used to determine the limit of detection and linear working range using the differential pulse polarographic technique. The present method was successfully used for the simultaneous determination of nicotinamide and pyridoxine hydrochloride, and for the determination of nicotinamide in multivitamin pharmaceutical preparations.