Analytical Sciences

Advancement of Flow-based Analysis with Alternative Chemical Reactions and New Devices for Environmental and Biological Samples

Tadao SAKAI and Norio TESHIMA

Department of Applied Chemistry, Aichi Institute of Technology, 1247 Yachigusa, Yakusa, Toyota 470-0392, Japan

This review includes our researches and other methodologies related to flow-based techniques, such as flow injection analysis (FIA) and sequential injection analysis (SIA). The methods will demonstrate semi-and full automated FIA and SIA, including liquid-liquid and liquid-solid extraction. FIA using alternative chemical reactions in the aqueous solution was applied to the trace analysis of metals in biological and environmental samples. For durable liquid-liquid extraction, several phase separators were designed. Moreover, multi-channel FIA with newly designed flow cells and SIA with lab-on-valve devices have been used for the simultaneous and successive determination of metals and organic compounds. On-line solid phase extraction (SPE) has also been proposed for highly sensitive analysis of organic and inorganic compounds.

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