Abstract − Analytical Sciences, 23(3), 277 (2007).
Integration of a Nanoporous Platinum Thin Film into a Microfluidic System for Non-enzymatic Electrochemical Glucose Sensing
Segyeong JOO,* Sejin PARK,** Taek Dong CHUNG,** and Hee Chan KIM***
*Interdisciplinary Program-Biomedical Engineering Major, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea
**Center for Nano-Bio Applied Technology and Department of Chemistry, Sungshin Women's University, Seoul 136-742, Korea
***Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Korea
**Center for Nano-Bio Applied Technology and Department of Chemistry, Sungshin Women's University, Seoul 136-742, Korea
***Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 110-744, Korea
In this paper, we describe an amperometric-type enzymeless glucose sensing system based on a nanoporous platinum (Pt) electrode embedded in a microfluidic chip. This microchip system is comprised of a microfluidic transport channel network and a miniaturized electrochemical cell for nonenzymatic glucose sensing. Sample and buffer solutions were transferred to the cell by programmed electroosmotic flow (EOF). A nanoporous Pt electrode with the roughness factor of 200.6 was utilized to determine glucose concentrations in phosphate buffered saline (PBS) by the direct oxidation of glucose, without any separation process. The sensitivity of the developed system is 1.65 µA cm-2 mM-1 in the glucose concentration range from 1 - 10 mM in PBS.
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