Abstract − Analytical Sciences, 23(11), 1301 (2007).
Post-chemiluminescence Phenomenon of NBS-Luminol Reactions and Their Applications to Flow Injection Analysis of Piroxicam
Hao BAI,* Fei NIE,*,** and Jiuru LU*
*School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, P. R. China
**Department of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721007, P. R. China
**Department of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721007, P. R. China
A new post-chemiluminescence (PCL) reaction was observed when piroxicam was injected into the reaction mixture after the CL reaction of N-bromosuccinimide (NBS) and luminol. A possible reaction mechanism was proposed based on the studies of the CL kinetic characteristics, the CL spectra, fluorescence spectra and other experiments. A new flow injection CL method for the determination of piroxicam was established based on the PCL reaction. The relative standard deviation (RSD) for the determination of piroxicam was 1.2% (n = 11, c = 2.0 × 10-6 g/ml). The CL intensity responded linearly to the concentration of piroxicam in the range 1.0 × 10-7 - 1.0 × 10-5 g/ml (r = 0.9991). The detection limit was 4.0 × 10-8 g/ml. The method had been applied to the determination of piroxicam in tablets with satisfactory results.
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