Analytical Sciences

Chemiluminescence Sensor for the Determination of Perphenazine Based on a Molecular Imprinted Polymer

Weifen NIU,* Fei NIE,*^,** and Jiuru LU*

*School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, P. R. China
**Chemistry and Engineering Department, Baoji University of Arts and Science, Baoji 721007, P. R. China

A luminol-potassium ferricyanide-perphenazine CL reaction with high sensitivity for the determination of perphenazine was found. A perphenazine molecular imprinted polymer (MIP) was synthesized. Using the perphenazine MIP as a recognition material, a novel molecular imprinting-chemiluminescence (MI-CL) sensor for the determination of perphenazine was made based on the luminol-potassium ferricyanide-perphenazine CL reaction. The sensor displayed good selectivity and high sensitivity. The linear-response range of the sensor was 5.0 × 10^-8 - 1.0 × 10^-5 g/ml with a linear correlation coefficient of 0.9961. The detection limit was 2 × 10^-8 g/ml perphenazine and the relative standard deviation for 1.0 × 10^-6 g/ml perphenazine solution was 3.7% (n = 11). The sensor was applied to the determination of perphenazine in urine samples with satisfactory results.

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