Abstract − Analytical Sciences, 22(2), 313 (2006).
Spectrophotometric Determination of Anthracycline Anticancer Agents with Aluminum(III) and Chromazurol S in a Nonionic Surfactant Micellar Medium
Masahiro NAKAO, Chikako YAMAZAKI, Hiroshi TOMINAGA, Takako YAMAGUCHI, and Yoshikazu FUJITA
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
A simple and highly sensitive spectrophotometric method for the determination of anthracycline anticancer agents, such as Daunorubicin hydrochloride (DAU), was established by using aluminum(III) and Chromazurol S (CAS) in a nonionic surfactant micellar medium. In the case of determination of DAU, the apparent molar absorptivity was 1.3 × 105 dm3 mol-1 cm-1 at 615 nm. Beer's law was obeyed in the concentration range of 0.028 - 2.82 µg ml-1 for DAU. Owing to no need for solvent extraction, this method could be applied to assays of DAU and related drugs in pharmaceutical preparations.
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