Abstract − Analytical Sciences, 21(9), 1133 (2005).
Spectrophotometric Determination of Tranexamic Acid in Pharmaceutical Bulk and Dosage Forms
Tariq Mahmood ANSARI,* Asad RAZA,* and Atta-ur REHMAN**
*Department of Chemistry, Bahauddin Zakariya University, Multan 60800, Pakistan
**BioFine Pharmaceuticals (Pvt.) Ltd., Multan, Pakistan
**BioFine Pharmaceuticals (Pvt.) Ltd., Multan, Pakistan
In this study, a simple, fast, accurate and sensitive spectrophotometric method has been developed for the determination of tranexamic acid in bulk and pharmaceutical preparations. The method is based on the reaction of ninhydrin with the primary amino group of tranexamic acid in the basic medium at pH 8.0. The reaction produces a bluish-purple color which absorbs maximally at 565 nm. Beer's law was obeyed in the range of 3 - 40 µg ml-1 with molar absorptivity of 5.093 × 103 L mol-1 cm-1. The effects of various factors such as temperature, heating time, concentration of reagent, color stability and interferences were investigated to optimize the procedure. The results have been validated analytically and statistically. The proposed method has been applied for the determination of tranexamic acid in bulk and pharmaceutical preparations with good results.
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