Analytical Sciences

Normal-Phase HPLC Enantioseparation of Novel Chiral Metal Tetrahedrane-type Clusters on an Amylose-based Chiral Stationary Phase

Xia WANG,*^,** Wen-zhi LI,*** Quan-yi ZHAO,*^,** Yong-min LI,* and Li-ren CHEN*

*Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 342 Tianshui Road, Lanzhou 730000, People’s Republic of China
**Graduate School of the Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100039, People’s Republic of China
***College of Chemistry and Chemical Engineer, Liaocheng University, 34 Wenhua Road, Liaocheng, 252059, People’s Republic of China

In the present work, an amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) chiral stationary phase (CSP) was prepared by coating ADMPC on small-particle silica gel. This ADMPC-CSP was for the first time successfully applied to separate a series of novel chiral metal tetrahedrane-type clusters. Furthermore, the influence of a mobile-phase modifier (various alcohols added in the mobile phase), including its concentration and structure, and the structures of the clusters on the chiral separation and retention was investigated. The results suggest that not only the structure and concentration of alcohol in the mobile phase, but also the subtle structural differences in racemate can have a pronounced effect on the enantiomeric separation and retention.

J-STAGE: View this article in J-STAGE