Analytical Sciences

Abstract − Analytical Sciences, 21(12), 1533 (2005).

Preparation of a Novel Iodide-Selective Electrode Based on Iodide-Miconazole Ion-Pair and Its Application to Pharmaceutical Analysis
Fahimeh JALALI,* Mohammad J. RAJABI,* Gholamreza BAHRAMI,** and Mojtaba SHAMSIPUR*
*Department of Chemistry, Faculty of Sciences, Razi University, Kermanshah, Iran
**School of Pharmacy, Kermanshah University of Medical Science, Kermanshah, Iran
An iodide-miconazole ion-paired complex was used as a suitable ion-exchanger for the preparation of a plasticized-PVC membrane electrode. Among different solvent mediators tested, dioctylsebacate exhibited the proper response characteristics, including Nernstian slope of the calibration curve, fast response time and good reproducibility of the emf values. The electrode exhibits a Nernstian slope of -59.8 ± 0.5 mV decade-1 for I- ion over a concentration range of 1.0 × 10-5 - 1.0 × 10-2 M with a limit of detection of 7.0 × 10-6 M. The electrode displays a good selectivity for I- with respect to a number of inorganic and organic species. It can be used over a pH range of 2.5 - 8.5. The membrane sensor was successfully applied to the determination of iodide in water samples and blood serum, as well as in pharmaceutical products such as iodoquinol and thyroxin.