Abstract − Analytical Sciences, 20(8), 1231 (2004).
Validated Spectrophotometric Methods for the Determination of Amiodarone Hydrochloride in Commercial Dosage Forms Using p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone
Nafisur RAHMAN, Nadeem Ahmad KHAN, and Syed Najmul Hejaz AZMI
Department of Chemistry, Aligarh Muslim University, Aligarh-202002 U.P., India
Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as n-electron donor with p-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π-acceptors to give highly colored complex species which absorb maximally at 535 and 570 nm, respectively. Beer’s law is obeyed in the concentration ranges 10.0 - 360.0 and 2.0 - 65.0 µg ml-1 for methods A and B, respectively. Application of the proposed methods to commercial pharmaceutical tablets are presented.
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