Abstract − Analytical Sciences, 20(5), 821 (2004).
Voltammetric Determination of Tinidazole Using a Glassy Carbon Electrode Modified with Single-Wall Carbon Nanotubes
Chunhai YANG
Department of Chemistry, Hubei Institute for Nationalities, Enshi 445000, Hubei, P. R. China
An electrochemical method based on a single-wall carbon nanotubes (SWNTs) film-coated glassy carbon electrode (GCE) was described for the determination of tinidazole. In a 0.1 M Britton-Robinson buffer with a pH of 10.0, tinidazole yields a very sensitive and well-defined reduction peak at -0.78 V (vs. SCE) on a SWNTs-modified GCE. Compared with that on a bare GCE, the reduction peak of tinidazole increases significantly on the modified GCE. Thus, all of the experimental parameters were optimized and a sensitive voltammetric method is proposed for tinidazole determination. It is found that the reduction peak current is proportional to the concentration of tinidazole over the range from 5 × 10-8 to 4 × 10-5 M, and that the detection limit is 1 × 10-8 M at 3 min open-circuit accumulation. This new analysis method was demonstrated with tinidazole drugs.
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