Abstract − Analytical Sciences, 20(12), 1741 (2004).
Separation of Preservatives in Cosmetic Products by Micellar Electrokinetic Chromatography
Somsak SIRICHAI and Chakapong HASAJITTO
Department of Chemistry, Faculty of Science, Burapha University, Chonburi, Thailand
This paper describes the methodological optimization and validation of a simple micellar electrokinetic chromatography for the rapid simultaneous separation of 2-methyl-4-isothiazolin-3-one, methylparaben, ethylparaben, propylparaben, and butylparaben. By using a 30 mM phosphate buffer (pH 7.2) containing 30 mM sodium dodecyl sulfate (SDS), an applied voltage of 10 kV and a separation temperature of 40°C, a quantitative determination was achieved, resulting in an analysis time of approximately 4 min. Only dilution and filtration are needed before analysis. The parameters for validation, such as linear ranges, detection limits, accuracy, and precision, are also reported.
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