Abstract − Analytical Sciences, 19(8), 1145 (2003).
Flow-Injection ChemiluminescenceDetermination of Enalapril Maleate in Pharmaceuticals and Biological FluidsUsing Tris(2,2'-bipyridyl)ruthenium(II)
Nawal A. A. ALARFAJ
Chemistry Department, College of Science,Women Student-Medical Studies and Sciences Sections, King Saud University,P. O. Box 22452, Riyadh 11495, Saudi Arabia
A chemiluminescence (CL) method using flowinjection (FI) has been investigated for the rapid and sensitivedetermination of enalapril maleate. The method is based on the CL reactionof the drug with tris(2,2'-bipyridyl)ruthenium(II),Ru(bipy)32+ and acidic potassium permanganate. Afterselecting the best operating parameters, calibration graphs were obtainedover concentration ranges of 0.005 - 0.2 µg/ml and 0.7 - 100µg/ml with a detection limit (S/N = 2) of 1.0 ng/ml.The average % found was 99.9 ± 0.7 and 100.2 ± 0.3 for thetwo concentration ranges respectively. %RSD (n = 10) for 5.0µg/ml was 0.44. The method was successfully applied to thedetermination of enalapril maleate in dosage forms and biological fluidswithout interferences.
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