Analytical Sciences

Comparative Study of the Response of Membrane Electrodes Based on Calix[6]-arene and Calix[8]arene Derivatives to Organic Ammonium Ions

Takashi KATSU,*  Nozomi OKAKI,* Kiyoyuki WATANABE,** Kiyoka TAKAISHI,*** and Hirochika YOKOSU***

*Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan
**Criminal Investigation Laboratory, Okayama Prefectural Police Headquarters, 1-3-2, Tonda-cho, Okayama700-0816, Japan
***Tokyo Kasei Kogyo Co., Ltd., 6-15-9, Toshima, Kita-ku, Tokyo 114-0003, Japan

p-tert-Butylcalix[8]arene-octaacetic acid octaethyl ester and calix[8]arene-octaacetic acid octaethyl ester well recognized 2-phenylethylamine and phenylalanine methyl ester compared with the corresponding calix[6]arene derivatives. Moreover, the calix[8]arene derivatives, especially one having tert-butyl groups, gave better selectivity against biologically active amines having a complicated structure, such as norephedrine. We considered the interaction between calixarenes and organic ammonium ions from the viewpoint of molecular symmetries.

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