Abstract − Analytical Sciences, 19(4), 639 (2003).
Crystal Structure and Synthesis of 17α-(5-Chlorovaleroyloxy)-16β-methylpregna-4,6-diene-3,20-dione
Manuel SORIANO-GARCÍA,* Elena RAMÍREZ,** Eugene BRATOEFF,** Marisa CABEZA,** and Gerardo AGUIRRE-HERNÁNDEZ***
*Departamento de Bioestructura, Instituto de Química, UNAM, Circuito Exterior, Ciudad Universitaria, Coyoacán, México D. F. 04510, México
**Departamento de Farmacia, Facultad de Química, UNAM, Ciudad Universitaria, Coyoacán, México D. F. 04510, México
***Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Blvd. Industrial S/N, Tijuana, Baja California, México
**Departamento de Farmacia, Facultad de Química, UNAM, Ciudad Universitaria, Coyoacán, México D. F. 04510, México
***Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Blvd. Industrial S/N, Tijuana, Baja California, México
C27H37O4Cl is orthorhombic, P212121. The unit-cell dimensions at 293 K are a = 7.1388(15), b = 12.9836(14), c = 26.665(10)Å, V = 2471.5(10)Å3, Dx = 1.239 g/cm3, and Z = 4. The R value is 0.070 for 1458 observed reflections. The A, B, C and D rings occur in distorted envelope, distorted half-chair, chair, and envelope and a half-chair conformations. The molecules in the crystal are packed at the normal van der Waals distances.
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