Analytical Sciences

Novel Bilirubin-Based PVC Calcium Sensors

Wagiha H. MAHMOUD

Department of Chemistry, Faculty of Science, Ain Shams University, Abassia, Cairo, 11566, Egypt

Poly(vinyl chloride) membrane sensors for Ca(II) ions were constructed based on bilirubin (1,3,6,7-tetramethyl-4,5-dicarboxyethy-2,8-divinyl-[b-13]-dihydrobilenone) as a neutral carrier in the presence of various plasticizers (o-nitrophenyloctyl ether, dioctyl phethalate and dibutyl sebacate), which were used as solvent mediators to incorporate the carrier into the membranes. The role of plasticizers as a medium of complexation was demonstrated. The influences of an anionic excluder, the pH and foreign ions were investigated. The selectivity coefficients were measured by a separate solution method. Among the plasticizers used, o-nitrophenyloctyl ether gave the best selectivity in the presence of large concentrations of alkali and alkaline earth's metal ions. Using sensor number I, a linear calibration graph with a good Nernstian slope of 29.5 ± 0.8 mV was obtained for Ca(II) concentrations of 5 x 10^-7 - 10^-2 mol l^-1 with a detection limit of 3 x 10^-7 mol l^-1 (12 ppb). The sensor can be used for more than 3 months with good reproducibility and a fast response time of 10 s. The developed sensor has been successfully applied to the analysis of some pharmaceutical formulations, baby-food products and human plasma. Moreover, it can be used as an indicator sensor in the potentiometric titration of Ca(II) with EDTA.

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