Analytical Sciences

Spectrofluorometric Resolution of Closely Overlapping Drug Mixtures Using Chemometrics Methods

Yu-Zhen CAO,*^,**  Cui-Yun MO,*** Ji-gong LONG,** Hong CHEN,* Hai-Long WU,*** and Ru-Qin YU***

*Key Laboratory of New Packaging Materials & Technology of China National Packaging Corporation, Zhuzhou Institute of Technology, Zhuzhou, 412008, China
**Environmental Monitoring Central Station of Guangzhou City, NO. 95, Jixiang Road of Guangzhou City, Guangzhou, 510030, China
***College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China

A modified parallel factors analysis (PARAFAC) algorithm with a penalty diagonalization error (PDE), newly proposed by the present authors, was utilized to simultaneously resolve drug mixtures of propranolol (PRO), dipyridamole (DIP) and amiloride (AMI) without any loss of sensitivity. The analyses were performed in aqueous solution. The experimental results demonstrated that the profiles of the spectra and the concentrations could be accurately resolved using the PDE algorithm with a high sensitivity and stable repeatability. That is to say, the closely overlapping problem of the spectra could be easily solved. Furthermore, simultaneous determinations of three kinds of tablets, which contain PRO, AMI and DIP, respectively, were successfully performed with satisfactory results.

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