Analytical Sciences

Fluorescent Molecular Recognition for Endocrine-Disrupting Chemicals and Their Analogs by Fluorescent Hetero-Modified Cyclodextrins

Miyuki NARITA, Nobuaki OGAWA, and Fumio HAMADA  

Department of Materials-process Engineering and Applied Chemistry for Environments, Faculty of Engineering and Resource Science, Akita University, Tegata, Akita 010-8502, Japan

Fluorescent molecular sensing for endocrine-disrupting chemicals and their analogs has been studied by investigating the fluorescence spectral change of regio-selective dansyl-tosyl-modified beta- and gamma-cyclodextrins upon the addition of a guest. These host compounds show pure monomer fluorescence at around 526 nm; the intensities of the guest-induced fluorescence either increase or decrease according to the accommodation of such guests as dioxin analogs, p-nonylphenol, 2,4-dichlorophenoxyacetic acid, bisphenol A, and diethylphthalate. The extent of the fluorescence variations with the guest is employed to display the sensing abilities of these hosts. The sensing parameter, deltaI/I ⁰ , was used to describe the sensing ability of the hosts, where I and I ⁰ are the fluorescence intensities in the presence and absence of a guest and deltaI=I-I ⁰ . These hosts exhibit highly sensitive and selective molecular-recognition ability, particularly for 2,4,6-trichlorophenol and bisphenol A.

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