Analytical Sciences

Electrochemical Coating with Poly(phenylene oxide) Films Bearing Oligoether Groups as a Tool for Elimination of Protein Adsorption to Electrode Surfaces

Hatsuo MAEDA, Tamaki OKADA, Yoriko MATSUMOTO, Kazunori KATAYAMA, Yuji YAMAUCHI and Hidenobu OHMORI

Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka, Suita, Osaka 565-0871, Japan

Reported herein are the adsorption properties of bovine serum albumin to glassy carbon (GC) electrodes coated with poly(phenylene oxide) (PPO) films formed by anodic polymerization of HOC₆H₄R in phosphate buffer (pH 7.4), where R=o-, m-, and p-MeO^- or m-Me(OCH₂CH₂)_nO- (n=1 - 4) group. Evaluation of the voltammetric response of caffeic acid demonstrated that a GC electrode coated with a PPO film derived from m-HOC₆H₄O(CH₂CH₂O)₄Me not only shows satisfactory electrochemical performance but also resists surface fouling due to protein adsorption. Coating with the film also proved to be useful in preventing the surface of a gold electrode from being fouled by protein adsorption. (Keywords: Protein adsorption, poly(phenylene oxide) film, modified electrode, bovine serum albumin, cyclic voltammetry)

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