Abstract − Analytical Sciences, 15(2), 141 (1999).
High Performance Cocktail Functional Monomer for Making Molecule Imprinting Polymer
Zihui MENG, Jinfang WANG, Liangmo ZHOU * , Qinghai WANG and Daoqian ZHU
Dalian Institute of Chemical and Physics, Chinese Academy of Sciences, Dalian, 116012, People's Republic of China
In order to make a molecule imprinting polymer (MIP) with highly chiral selectivity against N-t-Boc-L-Trp, a new kind of "cocktail" functional monomer: acrylamide+2-vinylpyridine was investigated. The MIP showed impressive chiral selectivity (α=3.23). With the increasing of water content in the mobile phase, ionic and hydrophobic interaction were found to be responsible for the chiral recognition process instead of the hydrogen bond. Tailing and peak asymmetry problems were overcome by using linear gradient elution. Physical properties such as thermal stability and pore structure for the MIP were also investigated. (Keywords: Molecule imprinting, enantiomer separation, chiral stationary phase, amino acid)
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