Abstract − Analytical Sciences, 15(12), 1227 (1999).
Flow-Injection Determination of Vitamin K3 by a Chemiluminescence Sensor
Yuming HUANG*, **, Zhiqiong CHEN*** and Zhujun ZHANG* +
*Department of Chemistry, Southwest Normal University, Beibei, Chongqing 400715, P. R. China
**Department of Chemistry, Nanjing University, Nanjing 210008, P. R. China
***Department of Chemistry, Chongqing Medical University, Chongqing 400016, P. R. China
**Department of Chemistry, Nanjing University, Nanjing 210008, P. R. China
***Department of Chemistry, Chongqing Medical University, Chongqing 400016, P. R. China
A chemiluminescence (CL) sensor for vitamin K3 (menadione sodium bisulfite, MSB) combined with a flow-injection system is presented in this paper. It is based on the auto-oxidation of bisulfite liberated from MSB in alkaline media in the presence of Tween 80 sensitized by Rhodamine 6G immobilized on a cation-exchange column. The sensor responds linearly to the MSB concentration in the range of 0.5 - 10 mg/ml with a detection limit (3 s) of 2.6 mg/l. The analysis can be performed within 1 min with a relative standard deviation of < 5%. The sensor is stable for over 250 determinations and has been successfully applied to the determination of MSB in injections and tablets. (Keywords: Chemiluminescence, flow injection, MSB, sensor)
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